Methane Waste Prevention Act of 2021 This bill establishes requirements to reduce methane emissions from the oil and natural gas sector. Methane is emitted during the production and transport of coal, natural gas, and oil. Specifically, the Environmental Protection Agency (EPA) must issue regulations that require the sector to reduce methane emissions over time. By 2025, methane emissions must be at least 65% below 2012 emissions. By 2030, the emissions must be at least 90% below 2012 emissions. The Department of the Interior must also establish regulations to reduce and prevent the waste of natural gas on federal land and Indian lands, including waste from venting, flaring, and fugitive releases. The regulations must include consistent enforcement mechanisms for any oil or gas operations that are not in compliance.