Metropolitan Areas Protection and Standardization Act of 2021 or the MAPS Act of 2021 This bill directs the Office of Management and Budget (OMB) to take specified steps before changing the standards for designating a core-based statistical area (CBSA). The standards are used to delineate metropolitan and micropolitan areas for statistical purposes. Specifically, before recommending, adopting, or implementing any change to the standards for a CBSA designation, the OMB must require the complete reporting of the use of CBSA designations, as standardized by the OMB; permit public comment on any proposed change to the standards for between 120 and 180 days; and submit a public report on the scientific basis, criteria, and methodology for any such change and the complete list of federal programs that would be impacted.