End Tuberculosis Now Act of 2021 This bill authorizes actions, including the provision of international assistance, to combat tuberculosis. The President may provide international assistance for the prevention, treatment, control, and elimination of tuberculosis. The President must also establish goals for U.S. efforts to detect, cure, and prevent all forms of tuberculosis globally by updating the U.S. Government Tuberculosis Strategy (2015-2019) and the National Action Plan for Combating Multidrug-Resistant Tuberculosis. The Government Accountability Office must periodically report to Congress on the impact of efforts to combat tuberculosis that are supported by U.S. bilateral assistance.